CBD for Anxiety and Depression in Women: A Safe and Effective Treatment Option

By Amy Chin
June 20, 2023

In recent years, cannabidiol (CBD) has gained popularity for its potential therapeutic benefits. Among the various potential uses of CBD, anxiety, and depression are two conditions that have garnered significant interest from researchers and the general public. This article aims to provide an overview of CBD’s potential benefits for anxiety and depression in women, discuss the legal landscape, and address common concerns.

What is CBD?

Cannabidiol (CBD) is a natural compound in the Cannabis sativa plant, including marijuana and hemp varieties. It is one of over 100 known cannabinoids, the active chemical compounds responsible for the plant’s various effects.

CBD is non-psychoactive, meaning it does not cause the “high” associated with marijuana use. It has gained popularity recently for its potential therapeutic benefits and is now used in various products, such as oils, tinctures, edibles, and topicals.

How CBD Interacts With the Body’s Endocannabinoid System

CBD interacts with the body’s endocannabinoid system (ECS), a complex cell-signaling system that plays a crucial role in maintaining homeostasis – the body’s natural state of balance. The ECS is composed of three main components:

  • Endocannabinoids (natural compounds similar to cannabinoids).
  • Receptors (CB1 and CB2).
  • Enzymes that break down endocannabinoids.

CBD does not bind directly to CB1 or CB2 receptors; instead, it is thought to modulate the ECS by inhibiting the breakdown of endocannabinoids, thereby increasing their levels in the body. This can lead to various potential health benefits, such as reduced inflammation, pain relief, and improved mood.

CBD for Anxiety and Depression

Among the various potential uses of CBD, anxiety, and depression are two conditions that have garnered significant interest from researchers and the general public.

CBD for Anxiety

Research on CBD for anxiety has shown promising results, although more extensive clinical studies are needed to understand its efficacy and safety fully. Some studies have suggested that CBD may help alleviate anxiety symptoms by:

  • Modulating serotonin levels: Serotonin is a neurotransmitter that plays a crucial role in mood regulation. CBD may interact with the serotonin receptors in the brain, helping to increase serotonin levels and improve mood.
  • Enhancing endocannabinoid signaling: The endocannabinoid system (ECS) regulates various physiological processes, including mood and stress response. CBD may improve the signaling of the ECS, helping to promote a sense of calm and relaxation.
  • Reducing inflammation: Chronic inflammation has been linked to anxiety and mood disorders. CBD has anti-inflammatory properties, which may help reduce inflammation in the brain and alleviate anxiety symptoms.

CBD for Depression

While research on CBD for depression is still in its early stages, some preclinical studies have shown promising results. CBD may potentially help with depression by:

  • Promoting neurogenesis: Depression has been linked to reduced hippocampal neurogenesis (creating new neurons in the brain). CBD may promote neurogenesis in the hippocampus, which could help alleviate depressive symptoms.
  • Modulating the HPA axis: The hypothalamic-pituitary-adrenal (HPA) axis is involved in the body’s stress response and has been implicated in depression. CBD may help regulate the HPA axis, reducing stress and potentially improving depressive symptoms.
  • Interacting with serotonin receptors: As mentioned earlier, CBD may interact with serotonin receptors in the brain, which could help improve mood and alleviate depression.

Potential Challenges for Women Seeking CBD Treatment: Accessibility and Affordability

Women seeking CBD treatment may face several challenges, including accessibility and affordability. Due to the varying legal status of CBD across states, women living in states with more restrictive CBD laws may have limited access to CBD products or may need to travel to neighboring states for legal access.

Additionally, the cost of CBD products can be prohibitive for some women. Health insurance typically does not cover CBD treatments, and the price of high-quality CBD products can be expensive. Furthermore, the lack of FDA regulation for CBD products raises concerns about the quality and safety of some products on the market.

Overcoming Barriers to CBD Usage for Women

Many women face financial barriers when it comes to accessing CBD products. To overcome these challenges, consider the following:

  • Research various CBD products and their prices to find the most affordable option.
  • Look for discounts, coupons, and bulk purchase options to save money on CBD products.
  • Communicate with your insurance provider to see if they cover any CBD products or if they can offer any financial assistance.

It’s essential to have open communication with your healthcare provider when considering CBD usage. Here are some tips to help you discuss CBD with your doctor:

  • Be honest about your interest in CBD and why it might help your condition.
  • Ask your doctor for their opinion and any concerns they may have about CBD usage.
  • Request information about potential drug interactions and side effects.
  • If your doctor is unfamiliar with CBD, offer them resources and research to help them better understand its potential benefits.

Legality and Common Issues Surrounding CBD for Women

The legal status of cannabidiol (CBD) varies depending on the country, state, and local laws. In the United States, the legal status of CBD is determined by the source of the compound and its concentration of tetrahydrocannabinol (THC), the psychoactive component of cannabis.

The 2018 Farm Bill legalized the cultivation of industrial hemp, defined as cannabis plants containing less than 0.3% THC. As a result, CBD products derived from hemp with less than 0.3% THC are considered legal at the federal level. However, CBD products derived from marijuana plants, which typically contain higher levels of THC, remain federally illegal and are classified as a Schedule I substance under the Controlled Substances Act.

Variations in CBD Legality: State and Federal Laws in the United States

While the federal government has legalized hemp-derived CBD, individual states can regulate and enforce their laws regarding CBD products. This means that the legality of CBD can vary from state to state.

Some states have fully legalized both recreational and medical marijuana, allowing for the use of CBD products derived from both hemp and marijuana plants. Other states have only legalized medical marijuana, which may require a doctor’s recommendation or prescription for patients to access CBD products. 

In some states, CBD is only legal for specific medical conditions, while others have not legalized CBD. Individuals need to research and understand the specific laws and regulations regarding CBD in their state of residence.


In conclusion, CBD has shown promising potential as a safe and effective treatment option for anxiety and depression in women. As research continues to evolve, women must stay informed about the legal landscape and potential challenges surrounding CBD usage.

By consulting with healthcare professionals, researching the specific laws in their state, and exploring various CBD products and brands such as Calm Better Days. Women can make informed decisions about incorporating CBD into their treatment plans. With open communication and a proactive approach, women can overcome barriers to CBD usage and potentially experience the therapeutic benefits of this natural compound for their mental health and well-being.