The Science Behind CBD and Hormonal Balance in Women

By Amy Chin
April 24, 2023

As the popularity of natural remedies and alternative medicine continues to rise, so does the interest in cannabidiol (CBD), a compound in the cannabis plant.Among its many potential benefits, CBD has been suggested to impact hormonal balance within the body positively. In this article, we delve into the basics of CBD, the endocannabinoid system, and how they interact with hormones.


What is CBD?


Cannabidiol (CBD) is a naturally occurring compound in the cannabis plant. It is one of over 100 cannabinoids, chemical compounds that interact with the human body’s endocannabinoid system. Unlike tetrahydrocannabinol (THC), the psychoactive component in cannabis responsible for producing the “high” sensation, CBD is non-psychoactive, meaning it does not produce any mind-altering effects.


The Endocannabinoid System and Hormonal Balance


Hormones are chemical messengers produced by glands in the endocrine system. They are secreted into the bloodstream and travel to various tissues and organs, regulating various body functions, including growth, metabolism, reproduction, and stress response. The ECS has been shown to regulate hormone production and release, which means that CBD, as a cannabinoid, can potentially help maintain hormonal balance.


Research has indicated that CBD may interact with the ECS to influence the release of hormones such as cortisol (the stress hormone), melatonin (which regulates the sleep-wake cycle), and insulin (which controls blood sugar levels). By modulating the levels of these hormones, CBD may help alleviate symptoms of hormonal imbalance, such as mood swings, insomnia, and metabolic disorders.


The Female Endocannabinoid System


The endocrine system is a network of glands and hormones that regulate various physiological processes, including growth, metabolism, and reproduction. In women, the primary endocrine organs include the hypothalamus, pituitary gland, ovaries, and adrenal glands. 


These glands secrete hormones like estrogen, progesterone, and cortisol, which work together to maintain the female reproductive system, regulate the menstrual cycle, and influence mood and stress responses.


The Endocannabinoid System: A Brief Overview


The ECS plays a crucial role in regulating the female reproductive system, and its interaction with female hormones is a subject of ongoing research.

 Some key interactions include:


  1. Estrogen and the ECS: Estrogen modulates the production and degradation of endocannabinoids, thereby influencing the ECS’s overall activity. High estrogen levels have been found to increase anandamide levels, while low estrogen levels are associated with decreased endocannabinoid activity. Additionally, estrogen regulates the expression of CB1 receptors in specific brain regions, impacting mood, stress, and pain perception.


  1. Progesterone and the ECS: Progesterone can also affect the ECS, as it has been shown to inhibit the synthesis of 2-AG, one of the primary endocannabinoids. This interaction can influence the ECS’s ability to regulate pain, mood, and other physiological functions.


  1. The ECS and the Menstrual Cycle: The endocannabinoid system regulates the menstrual cycle by modulating the secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus. This hormone, in turn, regulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which control ovarian function and hormone production.


  1. The ECS in Pregnancy: The ECS involves essential processes like implantation, embryo development, and labor. Disruptions in the ECS have been linked to pregnancy complications, such as preterm birth and preeclampsia.


The intricate relationship between the endocannabinoid system and female hormones is a fascinating area of study that holds the potential for further understanding and improving women’s health.


CBD and Menstrual Health


Premenstrual syndrome (PMS) encompasses a variety of physical and emotional symptoms experienced by many women in the days leading up to their period. These symptoms can include mood swings, irritability, bloating, and fatigue. Studies suggest CBD may help alleviate some PMS symptoms due to its anti-anxiety, antidepressant, and anti-inflammatory properties.


For instance, CBD can interact with serotonin receptors, crucial in mood regulation. This interaction may lead to a more balanced emotional state and reduced feelings of anxiety or depression. CBD’s anti-inflammatory properties can also help combat bloating and discomfort associated with PMS.


Some women experience irregularities in their menstrual cycles, such as missed periods or abnormal bleeding, which can be caused by various factors, including stress, hormonal imbalances, and underlying medical conditions. Although CBD is not a cure-all for menstrual irregularities, its potential to reduce stress and promote hormonal balance may help regulate the menstrual cycle. 


By reducing cortisol levels, CBD can help the body manage stress, which may contribute to a more regular menstrual cycle. Furthermore, CBD’s interaction with the endocannabinoid system may play a role in balancing hormones, leading to improved menstrual health.


CBD and Menopause


Menopause is a natural phase in a woman’s life that marks the end of her reproductive period. This transition, usually between 45 and 55, can be accompanied by physical and emotional symptoms. While hormone replacement therapy (HRT) has been the traditional treatment for menopausal symptoms, many women are now turning to CBD as a natural alternative. 


How CBD Can Help Manage Menopausal Symptoms:


Hot Flashes and Night Sweats: Hot flashes are a common symptom of menopause, experienced by up to 75% of women. They can lead to sudden feelings of warmth, redness, and sweating. Studies have suggested that CBD may help regulate body temperature and reduce hot flashes by interacting with the endocannabinoid system (ECS), which is crucial in maintaining homeostasis.


Sleep Disturbances: Insomnia and disrupted sleep are common issues during menopause. CBD can potentially improve sleep quality by reducing anxiety and promoting relaxation. Regular use of CBD may help women achieve better sleep patterns, thus improving their overall well-being during menopause.


Mood Swings and Anxiety: Hormonal fluctuations during menopause can lead to mood swings, anxiety, and depression. CBD has been found to have anxiolytic and antidepressant properties, which may help stabilize mood and reduce these emotional symptoms.


CBD’s Potential for Bone Health During Menopause:


A significant concern for postmenopausal women is the increased risk of osteoporosis and bone fractures due to declining estrogen levels. Research has indicated that CBD may help promote bone health by stimulating bone formation and reducing bone resorption. By potentially improving bone density, CBD can help women maintain stronger bones during and after menopause.


CBD and Hormonal Imbalances Associated with Menopause

Menopause is marked by hormonal imbalances, primarily due to the decline in estrogen production. CBD has shown promise in regulating hormone levels by interacting with the ECS. By potentially balancing hormonal levels, CBD can help alleviate some of the symptoms associated with menopause, such as hot flashes, mood swings, and weight gain.


How to Use CBD for Hormonal Balance


There are several types of CBD products available on the market, each offering unique benefits and methods of consumption. These include:


  • CBD Oil and Tinctures: These are liquid forms of CBD that can be taken sublingually (under the tongue) or added to food and beverages.
  • CBD Capsules and Soft Gels: Easy-to-swallow capsules containing a specific dosage of CBD.
  • CBD Edibles: These include gummies, chocolates, and other treats infused with CBD.
  • CBD Topicals: Creams, balms, and lotions that can be applied directly to the skin.
  • CBD Vape Products: E-liquids and vape pens allow users to inhale CBD for quicker absorption.


Recommended Dosages for Women


When using CBD for hormonal balance, starting with a low dosage and gradually increasing it based on your body’s response is essential. Here are general guidelines for CBD dosing in women:


  1. Begin with a low dose of 10-15mg of CBD daily.
  2. Monitor your symptoms and side effects for a week.
  3. If needed, gradually increase the dosage by 5-10mg weekly until you find the optimal dose for your needs.
  4. Consult a healthcare professional experienced in CBD use to get personalized dosing recommendations.

Precautions and Possible Side Effects


While CBD is generally considered safe, it is important to be aware of the precautions and possible side effects when using it for hormonal balance:


  1. Consult with a healthcare professional before starting CBD, especially if you are pregnant, breastfeeding, or taking medications.
  2. Be aware of potential drug interactions. CBD may interact with certain medications, such as blood thinners and antidepressants.
  3. Choose high-quality CBD products from reputable sources to ensure product safety and efficacy.
  4. Possible side effects of CBD may include drowsiness, dry mouth, diarrhea, and changes in appetite or weight. If you experience any side effects, reduce the dosage or discontinue use and consult your healthcare provider.




In conclusion, CBD has shown promising potential for positively impacting hormonal balance in women. By interacting with the endocannabinoid system, CBD may help regulate the secretion of hormones like cortisol, melatonin, and insulin, improving mood, sleep, and metabolic function. 


Furthermore, CBD may help alleviate symptoms of PMS and menopause, including mood swings, hot flashes, and sleep disturbances. As you consider incorporating CBD into your wellness routine, choosing a reputable brand with quality products is essential. 


One such brand is Calm Better Days, which offers a range of CBD products specifically designed for women’s hormonal health. With third-party testing and transparent sourcing, you can trust Calm Better Days to provide safe and effective CBD products. Remember to consult with your healthcare provider before starting any new supplement regimen.